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Buy Omeprazole Drug essay paper online

Omeprazole is a drug that belongs to proton pump inhibitors. This drug decreases the acidic levels in a patient's stomach. It is used to treat the signs of GERD; The Gastro esophageal reflux disease. In addition, it is practical to contain the stomach conditions that are because of excessive acid and its administration results to the healing of erosive esophagitis. This illness is due to the acid effect on a patient's stomach (Kiley, Craqin & Roth, 2007). The administration of Omeprazole at par with other relative antibiotics is able to treat the gastric ulcers that are because of the infections that are caused by Helicobacter pylori.

The administration of the drug has the possibility of increasing the blood concentrations of Diazepam or the so referred to as Valium, and Warfarin which is known as Coumadin. Omeprazole has the ability to raise the blood levels of Phenytoin or Dilantin in the blood plasma. This effect is made possible by the decrease in the liver elimination of the drug. Drug absorption is affected by the stomach acidity (Kiley, Craqin & Roth, 2007). Due to this, Omeprazole administration checks the absorption and the blood concentration of ketoconazole or Nizoral and raises the absorption and concentration of Digoxin also known as Lanoxin in blood plasma. The variations that are caused by Omeprazole in this case are likely to reduce ketoconazole effectiveness or increase the toxicity of Digoxin.

There are chances too that, Omeprazole administration, is able to raise the blood levels of Saquinavir as well as checking the levels of Nelfinaivir and Atazanavir in the blood plasma. These drugs are administered to patients who are sufferers of any infections that are due to Human immunodeficiency Virus (HIV). It is critical that the Saquinavir dosage has to be reduced to avoid toxicity in a patient and the increment of Nelfinavir and Atazanavir is critical for maintaining effectiveness. Enzymes in the liver, converts Clopidogrel or Plavix into its active form. Administration of Omeprazole checks the effects of the enzymes and has the potential of clopidogrel activity reduction. The administrating of Omeprazole should however never be the same time as clopodogrel.

Omeprazole increases the levels of cilostazol. This is also known as Pletal. Pletal dosage should be checked from it's twice administration of 100mg to 50 mg if it is accompanied or administered together with Omeprazole. Each of the packages that contain the Zegerid powder that is used for the oral suspension is composed of 460 mg of sodium. This translates to 304 mg of sodium for each of the Omeprazole capsules. Omeprazole has an active ingredient of the delayed release capsules. This is a strong surrogate Benzimidazole.

It's composition is as follows; 5-methoxy-2-[[(4-methoxy3, 5-dimethyl-2-pyridinyl) methyl] sulfinyl]-1H-benzimidazole (Bykowski, 2005).This compound is the factor that is responsible for the inhibition of the secretion of Gastric acid. It has an empirical formula of C17H19N3O3S, and its molecular weight is equal to the value of 345.42. Its structural formula enables it to melt at 155 degrees celcious. This because it is one of weak bases which are slightly soluble in water. Omeprazole stability is reliant on the pH. At stronger acidic conditions such as at the range of 2 and 4, Omeprazole is very stable. It has reasonable stability in alkaline surrounding though not the stronger ones. Alkaline conditions that range from a pH of 7.5 to 9, supports the stability of Omeprazole. The oral suspension Omeprazole half-life is dependent on the pH reading.

Absorption of Omeprazole takes place in the small intestines (Hochwald & Farrington, 2006). It is a 3-6 hours process and its systematic bioavailability is nearly 61%. The bioavailability of Omeprazole is affected by the food presence in the stomach. Thus, it is advisable that patients are supposed to take Omeprazole on an empty stomach using a glass of water. It is critical, that for absorption purposes, one should go without food for at least 1 hour and another 1-hour after taking it. This is set to curb the impairment that results from the presence on food items in the patient's stomach. Omeprazole binding with the plasma protein rated at nearly 97%.

After it taking it, Omeprazole is metabolized by cytochrome P450. This is mainly found in the liver. The drug can be quantified in plasma for monitoring therapies and diagnosis confirmation of case related to poisoning. The concentrations of Omeprazole in serum are between ranges of 0.23 to 1.2 mg/L. This is measured in patients who receive the drug via the oral route. It is also reasonable to distinguish Esomeprazole from the Racemic Omeprazole. This is made possible by the use of Enantiomeric chromatographic method.
Various pH measures are notable in different parts of the body. In Duodenum, a pH of 5.5 is the expectation while in the stomach it is in the range of 1.0to 3.5 respectively. The intestinal pH is likely to read 5.3 while the blood plasma will have varied readings. The arterial blood reads a pH of 7.40 while the venous blood has a notable pH of 7.39. Human fluids pH ranges 7.2 to 7.4 on PH scale (ICON Health, 2004). The percentages on ionization are 76% in the stomach while 62% is notable in the duodenum. These are based on estimates by pKa.

Basing on the above discussions, Omeprazole drug is an effective approach to the treatment of various acids based illnesses. These includes gastric and the duodenal ulcers, the erosive esophagitis as well as GERD. It also assists to contain Ellison syndrome and dyspepsia. The proton Pump inhibitor, performance is related to the decreasing of the acid that id produced by the stomach.

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